We investigated the in vivo efficacy of tigecycline, a new glycylcycline (a tetracycline derivative), in the management of methicillin-resistant Staphylococcus aureus (MRSA)-infected experimental surgical wounds in rats. The main outcome measures were quantitative bacterial culture, histological examination and immunohistochemical expression of matrix metalloproteinase-9 (MMP-9) and collagen IV.
Tigecycline accelerates staphylococcal-infected burn wound healing through matrix metalloproteinase-9 modulation
Simonetti O;Cirioni O;Lucarini G;Ghiselli R;Silvestri C;Brescini L;Guerrieri M;Di Primio R;Giacometti A;Offidani A
2012-01-01
Abstract
We investigated the in vivo efficacy of tigecycline, a new glycylcycline (a tetracycline derivative), in the management of methicillin-resistant Staphylococcus aureus (MRSA)-infected experimental surgical wounds in rats. The main outcome measures were quantitative bacterial culture, histological examination and immunohistochemical expression of matrix metalloproteinase-9 (MMP-9) and collagen IV.File in questo prodotto:
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