The desire of eternal youth seems to be as old as mankind. However, the increasing life expectancy experienced by populations in developed countries also involves a significantly increased incidence of the most common age-related diseases (ARDs). Senescent cells (SCs) have been identified as culprits of organismal aging. Their number rises with age and their senescence-associated secretory phenotype fuels the chronic, pro-inflammatory systemic state (inflammaging) that characterizes aging, impairing the regenerative ability of stem cells and increasing the risk of developing ARDs. A variegated class of molecules, including synthetic senolytic compounds and natural compounds contained in food, have been suggested to possess anti-senescence activity. Senolytics are attracting growing interest, and their safety and reliability as anti-senescence drugs are being assessed in human clinical trials. Notably, since SCs spread inflammation at the systemic level through pro-oxidant and pro-inflammatory signals, foods rich in polyphenols, which exert antioxidant and anti-inflammatory actions, have the potential to be harnessed as "anti-senescence foods" in a nutraceutical approach to healthier aging. We discuss the beneficial effects of polyphenol-rich foods in relation to the Mediterranean diet and the dietary habits of long-lived individuals, and examine their ability to modulate bacterial genera in the gut.
Anti-senescence compounds: A potential nutraceutical approach to healthy aging / Gurău, Felicia; Baldoni, Simone; Prattichizzo, Francesco; Espinosa, Emma; Amenta, Francesco; Procopio, Antonio Domenico; Albertini, Maria Cristina; Bonafè, Massimiliano; Olivieri, Fabiola. - In: AGEING RESEARCH REVIEWS. - ISSN 1872-9649. - 46:(2018), p. 14-31. [10.1016/j.arr.2018.05.001]