Chronic pain is nowadays considered not only the mainstay symptom of rheumatic diseases but also "a disease itself." Pain is a multidimensional phenomenon, and in inflammatory arthritis, it derives from multiple mechanisms, involving both synovitis (release of a great number of cytokines) and peripheral and central pain-processing mechanisms (sensitization). In the last years, the JAK-STAT pathway has been recognized as a pivotal component both in the inflammatory process and in pain amplification in the central nervous system. This paper provides a summary on pain in inflammatory arthritis, from pathogenesis to clinimetric instruments and treatment, with a focus on the JAK-STAT pathway.

Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets - A Focus on the JAK-STAT Pathway / Salaffi, Fausto; Giacobazzi, Giovanni; Di Carlo, Marco. - In: PAIN RESEARCH & MANAGEMENT. - ISSN 1203-6765. - ELETTRONICO. - 2018:(2018). [10.1155/2018/8564215]

Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets - A Focus on the JAK-STAT Pathway

Salaffi, Fausto
Supervision
;
Di Carlo, Marco
2018-01-01

Abstract

Chronic pain is nowadays considered not only the mainstay symptom of rheumatic diseases but also "a disease itself." Pain is a multidimensional phenomenon, and in inflammatory arthritis, it derives from multiple mechanisms, involving both synovitis (release of a great number of cytokines) and peripheral and central pain-processing mechanisms (sensitization). In the last years, the JAK-STAT pathway has been recognized as a pivotal component both in the inflammatory process and in pain amplification in the central nervous system. This paper provides a summary on pain in inflammatory arthritis, from pathogenesis to clinimetric instruments and treatment, with a focus on the JAK-STAT pathway.
2018
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/258592
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