Bisphosphonate-related osteonecrosis of the jaw (BRONJ), as other bone diseases, is supposed to be associated with an unbalanced bone remodeling process: thus, the full comprehension of the pathophysiology is fundamental to advance its treatment. Histological studies of morphometry and mineralization degree of jaw sites have shown many histopathological aspects [1]; however, there is also the need for quantitative three-dimensional (3D) imaging at the nanoscale. Recently, differences in lacunar morphology and peri-lacunar tissue properties at the submicrometer length scale were investigated by synchrotron radiation-based X-ray microtomography (SR-microCT) in human jaw bone samples obtained from both healthy subjects and patients suffering from BRONJ [2]....
Bisphosphonate-related Osteonecrosis of the Human Jaw: a combined 3D assessment of Bone Descriptors by Histology and Synchrotron Radiation-based Microtomography / Giuliani, Alessandra; Iezzi, Giovanna; Mozzati, Marco; Gallesio, Giorgia; Mazzoni, Serena; Tromba, Giuliana; Zanini, Franco; Piattelli, Adriano; Mortellaro, Carmen. - In: ORAL ONCOLOGY. - ISSN 1368-8375. - ELETTRONICO. - 82:(2018), pp. 200-202. [10.1016/j.oraloncology.2018.04.026]
Bisphosphonate-related Osteonecrosis of the Human Jaw: a combined 3D assessment of Bone Descriptors by Histology and Synchrotron Radiation-based Microtomography.
Giuliani Alessandra;Mazzoni Serena;
2018-01-01
Abstract
Bisphosphonate-related osteonecrosis of the jaw (BRONJ), as other bone diseases, is supposed to be associated with an unbalanced bone remodeling process: thus, the full comprehension of the pathophysiology is fundamental to advance its treatment. Histological studies of morphometry and mineralization degree of jaw sites have shown many histopathological aspects [1]; however, there is also the need for quantitative three-dimensional (3D) imaging at the nanoscale. Recently, differences in lacunar morphology and peri-lacunar tissue properties at the submicrometer length scale were investigated by synchrotron radiation-based X-ray microtomography (SR-microCT) in human jaw bone samples obtained from both healthy subjects and patients suffering from BRONJ [2]....I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
