Childhood type 1 diabetes has been shown an increase in Italy of 3.0% during 1990-2003. Aim of this study was to describe the incidence for type 1 diabetes in children 0-14 years in the same geographical area, during 2004-2013, according to gender, age and area of residence. Registry for type 1 diabetes mellitus in Italy (RIDI) is a coordination of local registries established in 1997. Eleven registries, distributed throughout the country, contributed to this analysis, covering more than 25% of the total Italian population. Cases were grouped into four macro-area of residence at diagnosis: North, Centre, South, and Sardinia. The incidence rates were age-standardized on the World Standard Population. 95% Confidence intervals (95%CI) were estimated assuming the Poisson distribution of cases. Rates were expressed per 100,000 person-years. Trend analysis of incidence was performed using a Poisson regression model. Ascertainment exceeded 90% in all registers. During the 10-year period 3643 subjects under 15 years of age developed type 1 diabetes. The highest incidence occurred in Sardinia for both males and females [41.8 (95%CI: 36.3-48.0) and 42.1 (95%CI: 36.4-48.7), respectively]. In the Peninsular Italy, the overall incidence was 14.5 (95%CI: 13.6-15.4) for males, and 13.1 (95%CI: 12.3-14.0) for females. No significant differences were found between the three geographical macro-areas and gender. A significant positive time trend was found in Sardinia and in South Italy, with an average increase of 2.6% (95%CI 0.6%-4.7%) and 3.9% (95%CI: 2.2%-5.6%) of new cases per year, respectively. During 2004-2013 the incidence rates of childhood diabetes were stable in North and Central Italy, whereas South Italy and Sardinia showed significantly increased rates. This pattern of change suggests that important risk exposures differed over time in different geographical area. Further time trend analysis and comparison of the patterns in defined regions is warranted
Incidence of childhood type 1 diabetes in Italy during 2004-2013 / Cherubini, V; Gesuita, R; Bruzzese, M; D'Annunzio, G; Ferrito, Lucia; Frongia, A; Iafusco, D; Iannilli, A; Iughetti, L; Lombardo, F; Piffer, S; Toni, S; Tumini, S; Skrami, E; Carle, F; Ridi Study, Group. - In: DIABETES. - ISSN 0012-1797. - 64:(2015), pp. A405-A405.
Incidence of childhood type 1 diabetes in Italy during 2004-2013
Gesuita R;FERRITO, LUCIA;Skrami E;Carle F;
2015-01-01
Abstract
Childhood type 1 diabetes has been shown an increase in Italy of 3.0% during 1990-2003. Aim of this study was to describe the incidence for type 1 diabetes in children 0-14 years in the same geographical area, during 2004-2013, according to gender, age and area of residence. Registry for type 1 diabetes mellitus in Italy (RIDI) is a coordination of local registries established in 1997. Eleven registries, distributed throughout the country, contributed to this analysis, covering more than 25% of the total Italian population. Cases were grouped into four macro-area of residence at diagnosis: North, Centre, South, and Sardinia. The incidence rates were age-standardized on the World Standard Population. 95% Confidence intervals (95%CI) were estimated assuming the Poisson distribution of cases. Rates were expressed per 100,000 person-years. Trend analysis of incidence was performed using a Poisson regression model. Ascertainment exceeded 90% in all registers. During the 10-year period 3643 subjects under 15 years of age developed type 1 diabetes. The highest incidence occurred in Sardinia for both males and females [41.8 (95%CI: 36.3-48.0) and 42.1 (95%CI: 36.4-48.7), respectively]. In the Peninsular Italy, the overall incidence was 14.5 (95%CI: 13.6-15.4) for males, and 13.1 (95%CI: 12.3-14.0) for females. No significant differences were found between the three geographical macro-areas and gender. A significant positive time trend was found in Sardinia and in South Italy, with an average increase of 2.6% (95%CI 0.6%-4.7%) and 3.9% (95%CI: 2.2%-5.6%) of new cases per year, respectively. During 2004-2013 the incidence rates of childhood diabetes were stable in North and Central Italy, whereas South Italy and Sardinia showed significantly increased rates. This pattern of change suggests that important risk exposures differed over time in different geographical area. Further time trend analysis and comparison of the patterns in defined regions is warrantedI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
