Background and Aims. Nutritional therapy is recommended for management of reactive hypoglycemia (RH), a condition characterized by hypoglycemia that occurs within four hours after a meal. The macrobiotic Ma-Pi 2 diet improves glycemic control in subjects with type 2 diabetes.We explored the effect of this diet on outcomes in non-diabetic individuals with RH. Materials and Methods. Twelve subjects with RH were randomized to the Ma-Pi 2 diet for three days and a control diet for three days in a randomized crossover design. Subjects received snacks on two days out of each three-day period only, and were monitored using continuous glucose monitoring. The 24-h period was divided into daytime (08:00–22:30 h [subdivided into ‘daytime without snacks’ and ‘daytime with snacks’]) and night-time (22:31–07:59 h). The effects of the two diets on the number of RH events (blood glucose <70 mg/dL [3.9 mmol/L]) and the percentage distribution of glucose readings within each of 16 glycemic intervals from <40 mg/dL (2.2 mmol/L) to >180 mg/dL (4.4 mmol/L) were determined. Results. There were significantly fewer RH events on the Ma-Pi 2 diet than the control diet during daytime without snacks (−2.5 events; 95% CI: -7.5, 0.0; P = 0.022) and daytime with snacks (−4.25 events; 95% CI: -7.5; −2.0; P = 0.013) but no difference at night. The percentage of glucose readings in the interval 71–80 mg/dL (3.9–4.4 mmol/L) was significantly higher on the control diet during daytime with and without snacks (P = 0.03 for both), while the percentage of glucose readings in the interval 91–100 mg/dL (5.1–5.6 mmol/L) was significantly higher on the Ma-Pi 2 diet during daytime without snacks (P = 0.02). Conclusions. The macrobiotic Ma-Pi 2 diet reduced blood glucose excursions during the day, thereby facilitating glycemic control in subjects with RH. The Ma-Pi 2 diet represents an effective nutritional tool for management of RH
Treatment of reactive hypoglycemia with the macrobiotic Ma-pi 2 diet as assessed by continuous glucose monitoring: The MAHYP randomized crossover trial / Soare, Andreea; Khazrai, Yeganeh Manon; Fontana, Lucia; Del Toro, Rossella; Lazzaro, Maria Concetta; Di Rosa, Claudia; Buldo, Antonia; Fioriti, Elvira; Maddaloni, Ernesto; Angeletti, Silvia; Di Mauro, Antonio; Gesuita, Rosaria; Skrami, Edlira; Tuccinardi, Dario; Fallucca, Sara; Pianesi, Mario; Pozzilli, Paolo. - In: METABOLISM, CLINICAL AND EXPERIMENTAL. - ISSN 0026-0495. - ELETTRONICO. - 69:(2017), pp. 148-156. [10.1016/j.metabol.2017.01.023]
Treatment of reactive hypoglycemia with the macrobiotic Ma-pi 2 diet as assessed by continuous glucose monitoring: The MAHYP randomized crossover trial
GESUITA, Rosaria;SKRAMI, Edlira;
2017-01-01
Abstract
Background and Aims. Nutritional therapy is recommended for management of reactive hypoglycemia (RH), a condition characterized by hypoglycemia that occurs within four hours after a meal. The macrobiotic Ma-Pi 2 diet improves glycemic control in subjects with type 2 diabetes.We explored the effect of this diet on outcomes in non-diabetic individuals with RH. Materials and Methods. Twelve subjects with RH were randomized to the Ma-Pi 2 diet for three days and a control diet for three days in a randomized crossover design. Subjects received snacks on two days out of each three-day period only, and were monitored using continuous glucose monitoring. The 24-h period was divided into daytime (08:00–22:30 h [subdivided into ‘daytime without snacks’ and ‘daytime with snacks’]) and night-time (22:31–07:59 h). The effects of the two diets on the number of RH events (blood glucose <70 mg/dL [3.9 mmol/L]) and the percentage distribution of glucose readings within each of 16 glycemic intervals from <40 mg/dL (2.2 mmol/L) to >180 mg/dL (4.4 mmol/L) were determined. Results. There were significantly fewer RH events on the Ma-Pi 2 diet than the control diet during daytime without snacks (−2.5 events; 95% CI: -7.5, 0.0; P = 0.022) and daytime with snacks (−4.25 events; 95% CI: -7.5; −2.0; P = 0.013) but no difference at night. The percentage of glucose readings in the interval 71–80 mg/dL (3.9–4.4 mmol/L) was significantly higher on the control diet during daytime with and without snacks (P = 0.03 for both), while the percentage of glucose readings in the interval 91–100 mg/dL (5.1–5.6 mmol/L) was significantly higher on the Ma-Pi 2 diet during daytime without snacks (P = 0.02). Conclusions. The macrobiotic Ma-Pi 2 diet reduced blood glucose excursions during the day, thereby facilitating glycemic control in subjects with RH. The Ma-Pi 2 diet represents an effective nutritional tool for management of RHI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
