The normobaric oxygen paradox states that a short exposure to normobaric hyperoxia followed by rapid return to normoxia creates a condition of 'relative hypoxia' which stimulates erythropoietin (EPO) production. Alterations in glutathione and reactive oxygen species (ROS) may be involved in this process. We tested the effects of short-term hyperoxia on EPO levels and the microcirculation in critically ill patients.

Effects of short-term hyperoxia on erythropoietin levels and microcirculation in critically Ill patients: a prospective observational pilot study

DONATI, Abele;DAMIANI, ELISA;ZUCCARI, SAMUELE;DOMIZI, ROBERTA;SCORCELLA, CLAUDIA;GIULIETTI, ALESSIA;VIGNINI, Arianna;ADRARIO, Erica;ROMANO, Rocco;MAZZANTI, LAURA;PELAIA, Paolo;
2017-01-01

Abstract

The normobaric oxygen paradox states that a short exposure to normobaric hyperoxia followed by rapid return to normoxia creates a condition of 'relative hypoxia' which stimulates erythropoietin (EPO) production. Alterations in glutathione and reactive oxygen species (ROS) may be involved in this process. We tested the effects of short-term hyperoxia on EPO levels and the microcirculation in critically ill patients.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/246165
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