The normobaric oxygen paradox states that a short exposure to normobaric hyperoxia followed by rapid return to normoxia creates a condition of 'relative hypoxia' which stimulates erythropoietin (EPO) production. Alterations in glutathione and reactive oxygen species (ROS) may be involved in this process. We tested the effects of short-term hyperoxia on EPO levels and the microcirculation in critically ill patients.
Effects of short-term hyperoxia on erythropoietin levels and microcirculation in critically Ill patients: a prospective observational pilot study / Donati, Abele; Damiani, Elisa; Zuccari, Samuele; Domizi, Roberta; Scorcella, Claudia; Girardis, Massimo; Giulietti, Alessia; Vignini, Arianna; Adrario, Erica; Romano, Rocco; Mazzanti, Laura; Pelaia, Paolo; Singer, Mervyn. - In: BMC ANESTHESIOLOGY. - ISSN 1471-2253. - ELETTRONICO. - 17:49(2017), pp. 1-10. [10.1186/s12871-017-0342-2]
Effects of short-term hyperoxia on erythropoietin levels and microcirculation in critically Ill patients: a prospective observational pilot study
DONATI, Abele;DAMIANI, ELISA;ZUCCARI, SAMUELE;DOMIZI, ROBERTA;SCORCELLA, CLAUDIA;GIULIETTI, ALESSIA;VIGNINI, Arianna;ADRARIO, Erica;ROMANO, Rocco;MAZZANTI, LAURA;PELAIA, Paolo;
2017-01-01
Abstract
The normobaric oxygen paradox states that a short exposure to normobaric hyperoxia followed by rapid return to normoxia creates a condition of 'relative hypoxia' which stimulates erythropoietin (EPO) production. Alterations in glutathione and reactive oxygen species (ROS) may be involved in this process. We tested the effects of short-term hyperoxia on EPO levels and the microcirculation in critically ill patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
