The Gleason grading system was developed in the late 1960s by Dr. Donald F. Gleason. Due to changes in prostatic adenocarcinoma (PAC) detection and treatment, newer technologies to better characterize prostatic pathology, subsequently described variants of PAC and further data relating various morphologic patterns to prognosis, the application of the Gleason grading system changed substantially in surgical pathology. First in 2005 and more recently in 2014, consensus conferences were held to update PAC grading. Here, we review of the successive changes in the grading of PAC from the original system, with emphasis on the newest prognostic grade grouping.
Prostate cancer: from Gleason scoring to prognostic grade grouping / Montironi, Rodolfo; Santoni, Matteo; Mazzucchelli, Roberta; Burattini, Luciano; Berardi, Rossana; Galosi, Andrea Benedetto; Cheng, Liang; Lopez Beltran, Antonio; Briganti, Alberto; Montorsi, Francesco; Scarpelli, Marina. - In: EXPERT REVIEW OF ANTICANCER THERAPY. - ISSN 1473-7140. - 16:4(2016), p. 433-40. [10.1586/14737140.2016.1160780]
Prostate cancer: from Gleason scoring to prognostic grade grouping
MONTIRONI, RODOLFO;SANTONI, MATTEO;MAZZUCCHELLI, Roberta;BERARDI, ROSSANA;GALOSI, Andrea Benedetto;SCARPELLI, Marina
2016-01-01
Abstract
The Gleason grading system was developed in the late 1960s by Dr. Donald F. Gleason. Due to changes in prostatic adenocarcinoma (PAC) detection and treatment, newer technologies to better characterize prostatic pathology, subsequently described variants of PAC and further data relating various morphologic patterns to prognosis, the application of the Gleason grading system changed substantially in surgical pathology. First in 2005 and more recently in 2014, consensus conferences were held to update PAC grading. Here, we review of the successive changes in the grading of PAC from the original system, with emphasis on the newest prognostic grade grouping.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
