Glyphosate (GLY) and organophosphorus insecticides such as chlorpyrifos (CPF) may cause DNA damage and cancer in exposed individuals through mitochondrial dysfunction. Polyphenols ubiquitously present in fruits and vegetables, have been viewed as antioxidant molecules, but also influence mitochondrial homeostasis. Here, honey containing polyphenol compounds was evaluated for its potential protective effect on pesticide-induced genotoxicity.
Organic honey supplementation reverses pesticide-induced genotoxicity by modulating DNA damage response / Alleva, Renata; Manzella, Nicola; Gaetani, Simona; Ciarapica, Veronica; Bracci, Massimo; Caboni, Maria Fiorenza; Pasini, Federica; Monaco, Federica; Amati, Monica; Borghi, Battista; Tomasetti, Marco. - In: MOLECULAR NUTRITION & FOOD RESEARCH. - ISSN 1613-4133. - STAMPA. - 60:10(2016), p. 2243-2255. [10.1002/mnfr.201600005]
Organic honey supplementation reverses pesticide-induced genotoxicity by modulating DNA damage response
MANZELLA, NICOLA;GAETANI, SIMONA;CIARAPICA, VERONICA;BRACCI, MASSIMO;MONACO, FEDERICA;AMATI, Monica;TOMASETTI, Marco
2016-01-01
Abstract
Glyphosate (GLY) and organophosphorus insecticides such as chlorpyrifos (CPF) may cause DNA damage and cancer in exposed individuals through mitochondrial dysfunction. Polyphenols ubiquitously present in fruits and vegetables, have been viewed as antioxidant molecules, but also influence mitochondrial homeostasis. Here, honey containing polyphenol compounds was evaluated for its potential protective effect on pesticide-induced genotoxicity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
