Biologic treatments have modified the therapeutic armamentarium in the treatment of many dermatological and non- dermatological diseases and data on literature have widely focused on the efficacy and safety of TNF-alpha inhibitors in psoriasis. Although the etiopathogenesis has not completely elucidated, inflammation appears the lait motif unifying the immune-pathogenesis of diverse skin disease, as atopic dermatitis, alopecia areata and hidradenitis suppurativa. Actually, data on the off-label use of biologics in cutaneous immune-mediated inflammatory diseases are scarce and restricted to anecdotal cases and case series. The present review aims to evidence the major off- label use of TNF-alpha inhibitors in dermatology.
Biologic Therapy in Inflammatory and Immunomediated Skin Diseases: Safety Profile / Ganzetti, Giulia; Campanati, Anna; Molinelli, Elisa; Offidani, Annamaria. - In: CURRENT DRUG SAFETY. - ISSN 1574-8863. - 11:1(2016), pp. 12-21.