Malignant mesothelioma (MM) is a highly aggressive tumor with poor prognosis. A major challenge is the development and application of early and highly reliable diagnostic marker(s). Serum biomarkers, such as 'soluble mesothelin-related proteins' (SMRPs), is the most studied and frequently used in MM. However, the low sensitivity of SMRPs for early MM limits its value; therefore, additional biomarkers are required. In this study, two epigenetically regulated markers in MM (microRNA-126, miR-126, and methylated thrombomodulin promoter, Met-TM) were combined with SMRPs and evaluated as a potential strategy to detect MM at an early stage.
Combined circulating epigenetic markers to improve mesothelin performance in the diagnosis of malignant mesothelioma / Santarelli, L., Staffolani, S., Strafella, E., Nocchi, L., Manzella, N., Grossi, P., Bracci, M., Pignotti, E., Alleva, R., Borghi, B., Pompili, C., Sabbatini, A., Rubini, C., Zuccatosta, L., Bichisecchi, E., Valentino, M., Horwood, K., Comar, M., Bovenzi, M., Dong, L.F., et al.. - In: LUNG CANCER. - ISSN 0169-5002. - 90:3(2015), pp. 457-464. [10.1016/j.lungcan.2015.09.021]
Combined circulating epigenetic markers to improve mesothelin performance in the diagnosis of malignant mesothelioma
SANTARELLI, Lory;STAFFOLANI, SARA;STRAFELLA, ELISABETTA;NOCCHI, LINDA;MANZELLA, NICOLA;GROSSI, PAOLA;BRACCI, MASSIMO;POMPILI, CECILIA;RUBINI, Corrado;VALENTINO, Matteo;AMATI, Monica;TOMASETTI, Marco
2015-01-01
Abstract
Malignant mesothelioma (MM) is a highly aggressive tumor with poor prognosis. A major challenge is the development and application of early and highly reliable diagnostic marker(s). Serum biomarkers, such as 'soluble mesothelin-related proteins' (SMRPs), is the most studied and frequently used in MM. However, the low sensitivity of SMRPs for early MM limits its value; therefore, additional biomarkers are required. In this study, two epigenetically regulated markers in MM (microRNA-126, miR-126, and methylated thrombomodulin promoter, Met-TM) were combined with SMRPs and evaluated as a potential strategy to detect MM at an early stage.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
