Growth factors are relatively small and stable, secreted or membrane-bound polypeptide ligands, which play an important role in proliferation, differentiation, angiogenesis, survival, inflammation, and tissue repair, or fibrosis. They exert multiple effects through the activation of signal transduction pathways by binding to their receptors on the surface of target cells. A number of studies have demonstrated the central role of growth factors and their signaling pathways in the pathogenesis of uterine leiomyomas. Numerous differentially expressed growth factors have been identified in leiomyoma and myometrial cells. These growth factors can activate multiple signaling pathways (Smad 2/3, ERK 1/2, PI3K, and β-catenin) and regulate major cellular processes, including inflammation, proliferation, angiogenesis, and fibrosis which are linked to uterine leiomyoma development and growth. In this chapter, we discuss the role of growth factors and their signaling pathways in the pathogenesis of uterine leiomyomas.

Growth factors and pathogenesis / Islam, MD SORIFUL; Greco, Stefania; Janjusevic, Milijana; Ciavattini, Andrea; Giannubilo, Stefano Raffaele; D'Adderio, Assunta; Biagini, Alessandra; Fiorini, Rosamaria; Castellucci, Mario; Ciarmela, Pasquapina. - In: BAILLIERE'S BEST PRACTICE & RESEARCH. CLINICAL OBSTETRICS & GYNAECOLOGY. - ISSN 1521-6934. - 34:(2016), pp. 25-36. [10.1016/j.bpobgyn.2015.08.018]

Growth factors and pathogenesis

ISLAM, MD SORIFUL;GRECO, STEFANIA;JANJUSEVIC, MILIJANA;CIAVATTINI, Andrea;GIANNUBILO, Stefano Raffaele;BIAGINI, ALESSANDRA;FIORINI, ROSAMARIA;CASTELLUCCI, Mario;CIARMELA, PASQUAPINA
2016-01-01

Abstract

Growth factors are relatively small and stable, secreted or membrane-bound polypeptide ligands, which play an important role in proliferation, differentiation, angiogenesis, survival, inflammation, and tissue repair, or fibrosis. They exert multiple effects through the activation of signal transduction pathways by binding to their receptors on the surface of target cells. A number of studies have demonstrated the central role of growth factors and their signaling pathways in the pathogenesis of uterine leiomyomas. Numerous differentially expressed growth factors have been identified in leiomyoma and myometrial cells. These growth factors can activate multiple signaling pathways (Smad 2/3, ERK 1/2, PI3K, and β-catenin) and regulate major cellular processes, including inflammation, proliferation, angiogenesis, and fibrosis which are linked to uterine leiomyoma development and growth. In this chapter, we discuss the role of growth factors and their signaling pathways in the pathogenesis of uterine leiomyomas.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/229008
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