Free hemoglobin (fHb) may induce vasoconstriction by scavenging nitric oxide. It may increase in older blood units due to storage lesions. This study evaluated whether old red blood cell transfusion increases plasma fHb in sepsis and how the microvascular response may be affected.
Plasma free hemoglobin and microcirculatory response to fresh or old blood transfusions in sepsis / Damiani, Elisa; Adrario, Erica; Luchetti, MICHELE MARIA; Scorcella, Claudia; Carsetti, Andrea; Mininno, Nicoletta; Pierantozzi, Silvia; Principi, Tiziana; Strovegli, Daniele; Bencivenga, Rosella; Gabrielli, Armando; Romano, Rocco; Pelaia, Paolo; Ince, Can; Donati, Abele. - In: PLOS ONE. - ISSN 1932-6203. - ELETTRONICO. - 10:5(2015), p. e0122655. [10.1371/journal.pone.0122655]
Plasma free hemoglobin and microcirculatory response to fresh or old blood transfusions in sepsis
DAMIANI, ELISA;ADRARIO, Erica;LUCHETTI, MICHELE MARIA;SCORCELLA, CLAUDIA;Carsetti, Andrea;PIERANTOZZI, SILVIA;GABRIELLI, ARMANDO;ROMANO, Rocco;PELAIA, Paolo;DONATI, Abele
2015-01-01
Abstract
Free hemoglobin (fHb) may induce vasoconstriction by scavenging nitric oxide. It may increase in older blood units due to storage lesions. This study evaluated whether old red blood cell transfusion increases plasma fHb in sepsis and how the microvascular response may be affected.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
