The worldwide prevalence of obesity has nearly doubled, with an increase in obesity-related cardiovascular disease and mortality. Several factors are involved in the genesis of hypertension and hypertensive heart disease (HHD) in overweight/obesity. This review is focused on bridging factors between excessive adiposity and HHD, presenting a unifying hypothesis of vascular-metabolic syndrome, where an "handicap" of the natriuretic peptide system has a central role both in adipocyte dysmetabolism as well as in increased blood pressure and HHD.
Hypertensive heart disease and obesity: a complex interaction between hemodynamic and non hemodynamic factors / Sarzani, Riccardo; Bordicchia, M.; Spannella, F.; DESSI' FULGHERI, Paolo Lorenzo; Fedecostante, M.; Spannella, Francesco. - In: HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION. - ISSN 1120-9879. - STAMPA. - 21:2(2014), pp. 81-87. [10.1007/s40292-014-0054-3]
Hypertensive heart disease and obesity: a complex interaction between hemodynamic and non hemodynamic factors.
SARZANI, Riccardo;DESSI' FULGHERI, Paolo Lorenzo;SPANNELLA, FRANCESCO
2014-01-01
Abstract
The worldwide prevalence of obesity has nearly doubled, with an increase in obesity-related cardiovascular disease and mortality. Several factors are involved in the genesis of hypertension and hypertensive heart disease (HHD) in overweight/obesity. This review is focused on bridging factors between excessive adiposity and HHD, presenting a unifying hypothesis of vascular-metabolic syndrome, where an "handicap" of the natriuretic peptide system has a central role both in adipocyte dysmetabolism as well as in increased blood pressure and HHD.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
