AIM: To assess the efficacy and safety of conservative surgical approach for microinvasive cervical cancer with regards to cone margins status and lymph vascular space invasion (LVSI). PATIENTS AND METHODS: This was a multicentre retrospective cohort study of 153 women diagnosed with microinvasive cervical cancer over a 10 years period (1993-2003). RESULTS: In conservatively-treated women (n=80), neither cancer mortality nor disease relapse after 184.5 ± 20.5 months of follow-up was detected. Residual disease in women who underwent secondary surgery was significantly related to positive margins on the primary cone excision (p=0.005) while no correlation with LVSI emerged. CONCLUSION: Conization can represent the definitive treatment for stage IA1, if surgical margins are cancer-free, independently of LVSI. A conservative surgical approach could also be considered in women with IA2 cervical cancer when preservation of fertility is strongly requested. A close long-term surveillance should be scheduled for conservatively-treated women.
Surgical approach and long-term clinical outcome in women with microinvasive cervical cancer / Sopracordevole, F.; Chiossi, G.; Barbero, M.; Cristoforoni, P.; Ghiringhello, B.; Frega, A.; Tortolani, F.; Boselli, F.; Clemente, Nicolo'; Ciavattini, Andrea; Italian Society of, Colposcopy; Cervico Vaginal, Pathology. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 34:8(2014), pp. 4345-4349.
Surgical approach and long-term clinical outcome in women with microinvasive cervical cancer
CLEMENTE, NICOLO';CIAVATTINI, Andrea;
2014-01-01
Abstract
AIM: To assess the efficacy and safety of conservative surgical approach for microinvasive cervical cancer with regards to cone margins status and lymph vascular space invasion (LVSI). PATIENTS AND METHODS: This was a multicentre retrospective cohort study of 153 women diagnosed with microinvasive cervical cancer over a 10 years period (1993-2003). RESULTS: In conservatively-treated women (n=80), neither cancer mortality nor disease relapse after 184.5 ± 20.5 months of follow-up was detected. Residual disease in women who underwent secondary surgery was significantly related to positive margins on the primary cone excision (p=0.005) while no correlation with LVSI emerged. CONCLUSION: Conization can represent the definitive treatment for stage IA1, if surgical margins are cancer-free, independently of LVSI. A conservative surgical approach could also be considered in women with IA2 cervical cancer when preservation of fertility is strongly requested. A close long-term surveillance should be scheduled for conservatively-treated women.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
