Objectives: Vascular endothelialgrowthfactor(VEGF)isapotentinduceroftumorangiogenesisandrepresentsthekeyelementinthe pathogenesis ofclearcellrenalcellcarcinoma(ccRCC).TheaimofthisstudywastoinvestigatetheuseoftumorVEGFexpressionasa parameter toidentifytumorstageandprognosticallydifferentpatientgroups. Methods andmaterials: We retrospectivelycollectedclinicaldataof137patientstreatedwithpartialorradicalnephrectomyatour institutions fororgan-confined, locallyadvanced,andmetastaticccRCCsbetween1984and2013.TumorcellVEGFimmunohistochemical expression wascomparedwithpathologicalandclinicalfeaturesincludingage,sex,tumorstage,andFuhrmangrade.ComparisonofVEGF expression levelsbetweentumorstageswasperformedviaKruskal-Wallisnonparametrictest.SurvivalanalysiswasconductedviaKaplan- Meier product-limitmethod,andMantel-Haenszellog-ranktestwasemployedtocomparesurvivalamonggroups. Results: Medianageatdiagnosiswas61years(range:33–85y).TumorstagewaspT1N0M0in67patients(49%),pT2N0M0in5(4%),and pT3N0M0in25(18%),while40patients(29%)hadmetastatictumorsat diagnosis.FuhrmannucleargradewasG1in22patients(16%),G2in60 (44%),G3in33(24%),G4in13patients(9%),andunknownin9patients. TumorVEGFwasdifferentiallyexpressedamongdifferentstages (P o 0.001)andinlow(G1–2)andhigh(G3–4) Fuhrmangradetumors(P o 0.001).Nosignificantdifferenceswerefoundwhenstratifyingbysex (P ¼ 0.06)orage(P ¼ 0.29).Medianoverallsurvival(OS)frompartialorradicalnephrectomywas161months(range:1–366).Weobserveda significantly longerOSinpatientswithlow(o25%)vs.high(425%)VEGFexpressionlevels(medianOS206vs.65mo, P o 0.001). Conclusions: OurdatashowthattumorcellVEGFexpressionissignificantly associatedwithtumorstageandFuhrmangradeandis able topredictpatientoutcome,suggestingapotentialuseofthisparameter inidentifyingprognosticallydifferentpatientswithccRCC.
Tumor VEGF expression correlates with tumor stage and identifies prognostically different groups in clear cell renal cell carcinoma patients / Minardi, Daniele; Santoni, Matteo; Lucarini, Guendalina; Mazzucchelli, Roberta; Burattini, L; Conti, Alessandro; Bianconi, Maristella; Scartozzi, Mario; Milanese, Giulio; DI PRIMIO, Roberto; Montironi, Rodolfo; Cascinu, Stefano; Muzzonigro, Giovanni. - In: UROLOGIC ONCOLOGY. - ISSN 1078-1439. - STAMPA. - 33:(2015), pp. 113.e1-113.e7. [10.1016/j.urolonc.2014.06.014]
Tumor VEGF expression correlates with tumor stage and identifies prognostically different groups in clear cell renal cell carcinoma patients
MINARDI, Daniele;SANTONI, MATTEO;LUCARINI, Guendalina;MAZZUCCHELLI, Roberta;CONTI, ALESSANDRO;BIANCONI, MARISTELLA;SCARTOZZI, MARIO;MILANESE, Giulio;DI PRIMIO, Roberto;MONTIRONI, RODOLFO;CASCINU, Stefano;MUZZONIGRO, GIOVANNI
2015-01-01
Abstract
Objectives: Vascular endothelialgrowthfactor(VEGF)isapotentinduceroftumorangiogenesisandrepresentsthekeyelementinthe pathogenesis ofclearcellrenalcellcarcinoma(ccRCC).TheaimofthisstudywastoinvestigatetheuseoftumorVEGFexpressionasa parameter toidentifytumorstageandprognosticallydifferentpatientgroups. Methods andmaterials: We retrospectivelycollectedclinicaldataof137patientstreatedwithpartialorradicalnephrectomyatour institutions fororgan-confined, locallyadvanced,andmetastaticccRCCsbetween1984and2013.TumorcellVEGFimmunohistochemical expression wascomparedwithpathologicalandclinicalfeaturesincludingage,sex,tumorstage,andFuhrmangrade.ComparisonofVEGF expression levelsbetweentumorstageswasperformedviaKruskal-Wallisnonparametrictest.SurvivalanalysiswasconductedviaKaplan- Meier product-limitmethod,andMantel-Haenszellog-ranktestwasemployedtocomparesurvivalamonggroups. Results: Medianageatdiagnosiswas61years(range:33–85y).TumorstagewaspT1N0M0in67patients(49%),pT2N0M0in5(4%),and pT3N0M0in25(18%),while40patients(29%)hadmetastatictumorsat diagnosis.FuhrmannucleargradewasG1in22patients(16%),G2in60 (44%),G3in33(24%),G4in13patients(9%),andunknownin9patients. TumorVEGFwasdifferentiallyexpressedamongdifferentstages (P o 0.001)andinlow(G1–2)andhigh(G3–4) Fuhrmangradetumors(P o 0.001).Nosignificantdifferenceswerefoundwhenstratifyingbysex (P ¼ 0.06)orage(P ¼ 0.29).Medianoverallsurvival(OS)frompartialorradicalnephrectomywas161months(range:1–366).Weobserveda significantly longerOSinpatientswithlow(o25%)vs.high(425%)VEGFexpressionlevels(medianOS206vs.65mo, P o 0.001). Conclusions: OurdatashowthattumorcellVEGFexpressionissignificantly associatedwithtumorstageandFuhrmangradeandis able topredictpatientoutcome,suggestingapotentialuseofthisparameter inidentifyingprognosticallydifferentpatientswithccRCC.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
