Circular and apparently trans-spliced RNAs have recently been reported as abundant types of transcripts in mammalian transcriptome data. Both types of non-colinear RNAs are also abundant in RNA-seq of different tissue from both the African and the Indonesian coelacanth. We observe more than 8,000 lincRNAs with normal gene structure and several thousands of circularized and trans-spliced products, showing that such atypical RNAs form a substantial contribution to the transcriptome. Surprisingly, the majority of the circularizing and trans-connecting splice junctions are unique to atypical forms, that is, are not used in normal isoforms. J. Exp. Zool. (Mol. Dev. Evol.) 322B: 342–351, 2014. © 2013 Wiley Periodicals, Inc.
Atypical RNAs in the coelacanth transcriptome / Anne, Nitsche; Gero, Doose; Hakim, Tafer; Mark, Robinson; Nil Ratan, Saha; Marco, Gerdol; Canapa, Adriana; Steve, Hoffmann; Chris T., Amemiya; Peter F., Stadler. - In: JOURNAL OF EXPERIMENTAL ZOOLOGY. PART B, MOLECULAR AND DEVELOPMENTAL EVOLUTION.. - ISSN 1552-5007. - 322:6(2014), pp. 342-351. [10.1002/jez.b.22542]
Atypical RNAs in the coelacanth transcriptome
CANAPA, Adriana;
2014-01-01
Abstract
Circular and apparently trans-spliced RNAs have recently been reported as abundant types of transcripts in mammalian transcriptome data. Both types of non-colinear RNAs are also abundant in RNA-seq of different tissue from both the African and the Indonesian coelacanth. We observe more than 8,000 lincRNAs with normal gene structure and several thousands of circularized and trans-spliced products, showing that such atypical RNAs form a substantial contribution to the transcriptome. Surprisingly, the majority of the circularizing and trans-connecting splice junctions are unique to atypical forms, that is, are not used in normal isoforms. J. Exp. Zool. (Mol. Dev. Evol.) 322B: 342–351, 2014. © 2013 Wiley Periodicals, Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
