The circadian clock can regulate the metabolic process of xenobiotics, but little is known as to circadian rhythms can be perturbed by xenobiotics. Styrene is a organic chemical widely used in occupational settings. The effects of styrene on the circadian genes of HuDE cells were evaluated after serum-shocking synchronization. A subtoxic dose of 100 µM of styrene altered the expression of clock genes BMAL1, PER2, PER3, CRY1, CRY2, and REV-ERB-α.
Styrene altered clock gene expression in serum-shocked cultured human fibroblasts / Manzella, Nicola; Bracci, Massimo; Staffolani, Sara; Strafella, Elisabetta; V., Rapisarda; Valentino, Matteo; Amati, Monica; A., Copertaro; Santarelli, Lory. - In: BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY. - ISSN 0916-8451. - 77:(2013), pp. 1296-1298.
Styrene altered clock gene expression in serum-shocked cultured human fibroblasts.
MANZELLA, NICOLA;BRACCI, MASSIMO;STAFFOLANI, SARA;STRAFELLA, ELISABETTA;VALENTINO, Matteo;AMATI, Monica;SANTARELLI, Lory
2013-01-01
Abstract
The circadian clock can regulate the metabolic process of xenobiotics, but little is known as to circadian rhythms can be perturbed by xenobiotics. Styrene is a organic chemical widely used in occupational settings. The effects of styrene on the circadian genes of HuDE cells were evaluated after serum-shocking synchronization. A subtoxic dose of 100 µM of styrene altered the expression of clock genes BMAL1, PER2, PER3, CRY1, CRY2, and REV-ERB-α.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
