A new class of different lipids bearing a nitroxide radical moiety was synthesized and used in the preparation of multilamellar phosphatidylcholine liposomes. Analysis of the corresponding EPR spectra allowed to get information about the distribution of these free radicals within the liposome structure, and the resulting antioxidant activity was measured by means of the TBARS assay. A correlation between the functionalised lipids antioxidant activity, their dipolar moment (computed by DFT) and their EPR features could be envisaged.
New Nitroxide functionalized Lipids with Antioxidant Activity / C., Petrocchi; Astolfi, Paola; Carloni, Patricia; Mobbili, Giovanna; Pisani, Michela; Stipa, Pierluigi. - STAMPA. - (2012), pp. 187-188. (Intervento presentato al convegno VIII Convegno Nazionale AICIng tenutosi a Aci Castello (CT) nel 16-19/09/2012).
New Nitroxide functionalized Lipids with Antioxidant Activity
ASTOLFI, PAOLA;CARLONI, PATRICIA;MOBBILI, Giovanna;PISANI, MICHELA;STIPA, Pierluigi
2012-01-01
Abstract
A new class of different lipids bearing a nitroxide radical moiety was synthesized and used in the preparation of multilamellar phosphatidylcholine liposomes. Analysis of the corresponding EPR spectra allowed to get information about the distribution of these free radicals within the liposome structure, and the resulting antioxidant activity was measured by means of the TBARS assay. A correlation between the functionalised lipids antioxidant activity, their dipolar moment (computed by DFT) and their EPR features could be envisaged.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
