Cellular senescence is a complex response to stress that contributes to suppress cancer and to initialize mechanisms of repair after tissue injury. However, the accumulation of senescent cells is considered a hallmark of aging and is believed to contribute to the aging phenotype and to drive age-related pathologies. For these reasons, modulation of this response is emerging as a promising therapeutic target in cancer and aging research. In particular, it is desirable to induce cellular senescence in cancer cells for the purpose of an anticancer therapy but, conversely, it is likely that preventing excessive accumulation of senescent cells during aging could help for the purpose of health maintenance and longevity. In this chapter we review the evidence that cellular senescence can be effectively targeted in vitro by various dietary bioactive compounds and will attempt to elucidate the mechanisms involved. We also discuss the problems that hamper the translation of these findings into the development of nutraceuticals for therapeutic purposes in vivo.
Nutritional Modulators of Cellular Senescence In Vitro / Provinciali, M.; Pierpaoli, E.; Piacenza, F.; Giacconi, R.; Costarelli, L.; Basso, A.; Recchioni, R.; Marcheselli, F.; Bray, D.; Benlhassan, K.; Malavolta, M.. - (2016), pp. 293-312. [10.1016/B978-0-12-801816-3.00022-4]
Nutritional Modulators of Cellular Senescence In Vitro
Malavolta M.Ultimo
Conceptualization
2016-01-01
Abstract
Cellular senescence is a complex response to stress that contributes to suppress cancer and to initialize mechanisms of repair after tissue injury. However, the accumulation of senescent cells is considered a hallmark of aging and is believed to contribute to the aging phenotype and to drive age-related pathologies. For these reasons, modulation of this response is emerging as a promising therapeutic target in cancer and aging research. In particular, it is desirable to induce cellular senescence in cancer cells for the purpose of an anticancer therapy but, conversely, it is likely that preventing excessive accumulation of senescent cells during aging could help for the purpose of health maintenance and longevity. In this chapter we review the evidence that cellular senescence can be effectively targeted in vitro by various dietary bioactive compounds and will attempt to elucidate the mechanisms involved. We also discuss the problems that hamper the translation of these findings into the development of nutraceuticals for therapeutic purposes in vivo.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
