Circadian rhythm (periodicity: 24 h) can modulate trends of indices based on the electrocardiogram (ECG), as ECG alternans (ABAB fluctuation of ECG waves; ECGA). This work aims to verify if circadian rhythm modulates ECGA in kidney failure patients - to our knowledge, not investigated yet - and to study the effect of dialysis treatment. ECGA was analyzed on 51 long-term (48 h on average) 12-lead ECG from end-stage renal disease (ESRD) patients. Acquisitions included dialysis, night after, and following day and night. Measures of P-wave, QRS-complex and T-wave alternans (PWA, QRSA, and TWA, respectively; μ V were obtained using the enhanced adaptive matched filter method. Results indicate that, in dialysis-free days, ECGA trend was affected by circadian modulation. PWA/QRSA/TWA trends reached their minima during the night and their maxima during the day (lead average, 7/9/16 μ V and 11/16/20 μ V, respectively; p<0.05). Dialysis interrupted ECGA circadian periodicity, reducing daytime PWA/QRSA/TWA (lead average, 8/12/17 μ V. Generally, ECGA values increased from dialysis to 24 h after, by +39%, +31% and +20% for PWA, QRSA, and TWA, respectively. Thus, in our ESRD population, circadian modulation affected ECGA, and dialysis treatment interrupted its periodicity, causing a decrement of ECGA.
Circadian Modulation of Electrocardiographic Alternans in Kidney Failure Patients on Dialysis / Marcantoni, I.; Leoni, C.; Peroni, C.; Sbrollini, A.; Morettini, M.; Burattini, L.. - In: COMPUTING IN CARDIOLOGY. - ISSN 2325-8861. - ELETTRONICO. - 49(2022):(2022), pp. 1-4. (Intervento presentato al convegno 2022 Computing in Cardiology, CinC 2022 tenutosi a Tampere, Finlandia nel 2022) [10.22489/CinC.2022.133].
Circadian Modulation of Electrocardiographic Alternans in Kidney Failure Patients on Dialysis
Marcantoni I.;Leoni C.;Sbrollini A.;Morettini M.;Burattini L.
2022-01-01
Abstract
Circadian rhythm (periodicity: 24 h) can modulate trends of indices based on the electrocardiogram (ECG), as ECG alternans (ABAB fluctuation of ECG waves; ECGA). This work aims to verify if circadian rhythm modulates ECGA in kidney failure patients - to our knowledge, not investigated yet - and to study the effect of dialysis treatment. ECGA was analyzed on 51 long-term (48 h on average) 12-lead ECG from end-stage renal disease (ESRD) patients. Acquisitions included dialysis, night after, and following day and night. Measures of P-wave, QRS-complex and T-wave alternans (PWA, QRSA, and TWA, respectively; μ V were obtained using the enhanced adaptive matched filter method. Results indicate that, in dialysis-free days, ECGA trend was affected by circadian modulation. PWA/QRSA/TWA trends reached their minima during the night and their maxima during the day (lead average, 7/9/16 μ V and 11/16/20 μ V, respectively; p<0.05). Dialysis interrupted ECGA circadian periodicity, reducing daytime PWA/QRSA/TWA (lead average, 8/12/17 μ V. Generally, ECGA values increased from dialysis to 24 h after, by +39%, +31% and +20% for PWA, QRSA, and TWA, respectively. Thus, in our ESRD population, circadian modulation affected ECGA, and dialysis treatment interrupted its periodicity, causing a decrement of ECGA.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
