The incretin effect is a phenomenon in which insulin response to an Oral Glucose Tolerance Test (OGTT) is higher with respect to the insulin response to a matched isoglycaemic intravenous glucose infusion (I-IGI). The aim of this study was to simplify our previous model describing glucose-insulin regulatory system to allow assessment of the incretin effect in healthy subjects from OGTT glucose and insulin data, without using I-IGI data. The proposed model is characterized by four free parameters and was tested on mean data of two groups of healthy subjects. Free model parameters were estimated with a good precision (CV%<22) and provided values for the incretin effect very similar to the experimental ones (64.2 vs. 63 in the first group of subject and 77.7 vs. 78.1 in the second group). Thus, the proposed model seems to be promising, for the sake of a patient-oriented approach, to assess the incretin effect in healthy subjects only using OGTT glucose and insulin data.
Model-based assessment of incretin effect from OGTT data in healthy subjects / Morettini, M.; Creato, E.; Di Monte, J.; Ilari, L.; Burattini, L.. - ELETTRONICO. - (2020), pp. 224-227. (Intervento presentato al convegno 7th National Congress of Bioengineering, GNB 2020 tenutosi a Trieste, Italia nel 2020).
Model-based assessment of incretin effect from OGTT data in healthy subjects
Morettini M.
;Creato E.;Di Monte J.;Burattini L.
2020-01-01
Abstract
The incretin effect is a phenomenon in which insulin response to an Oral Glucose Tolerance Test (OGTT) is higher with respect to the insulin response to a matched isoglycaemic intravenous glucose infusion (I-IGI). The aim of this study was to simplify our previous model describing glucose-insulin regulatory system to allow assessment of the incretin effect in healthy subjects from OGTT glucose and insulin data, without using I-IGI data. The proposed model is characterized by four free parameters and was tested on mean data of two groups of healthy subjects. Free model parameters were estimated with a good precision (CV%<22) and provided values for the incretin effect very similar to the experimental ones (64.2 vs. 63 in the first group of subject and 77.7 vs. 78.1 in the second group). Thus, the proposed model seems to be promising, for the sake of a patient-oriented approach, to assess the incretin effect in healthy subjects only using OGTT glucose and insulin data.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
