Hypoxemia is defined as a decrease in the partial pressure of oxygen in the blood. There are various mechanisms of hypoxemia: Ventilation-Perfusion (V/Q)mismatch and shunt are the most common causes of arterial hypoxia in newborns. Neonatologists often treat hypoxic infants in their clinical practice. A simple and rapid tool to evaluate the contribution of shuntand V/Q mismatch in oxygen dependent infants would be useful. We non-invasively studied six preterm infants with bronchopulmonary dysplasia, a condition in which V/Q mismatch and shunt may coexist. Our setup consisted of a high precision oximeter and a computerized algorithm to eliminate inaccurate oxygen saturation data. The relationship between fraction of inspired oxygen (FiO2) andarterial oxygen saturation(SpO2) was assessed using a previously described methodology. Most infants had V/Q mismatch, while one had prevalent shunt.
Computerized assessment of shunt and Ventilation-Perfusion mismatch in oxygen dependent infants / Marchionni, P; Palazzi, Ml; Scalise, L; Carneilli, Vp; Nobile, S. - ELETTRONICO. - (2018), pp. 684-688. (Intervento presentato al convegno 13th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2018 tenutosi a Roma nel 11-13 June 2018) [10.1109/MeMeA.2018.8438793].
Computerized assessment of shunt and Ventilation-Perfusion mismatch in oxygen dependent infants
Marchionni, P;Scalise, L;Nobile, S
2018-01-01
Abstract
Hypoxemia is defined as a decrease in the partial pressure of oxygen in the blood. There are various mechanisms of hypoxemia: Ventilation-Perfusion (V/Q)mismatch and shunt are the most common causes of arterial hypoxia in newborns. Neonatologists often treat hypoxic infants in their clinical practice. A simple and rapid tool to evaluate the contribution of shuntand V/Q mismatch in oxygen dependent infants would be useful. We non-invasively studied six preterm infants with bronchopulmonary dysplasia, a condition in which V/Q mismatch and shunt may coexist. Our setup consisted of a high precision oximeter and a computerized algorithm to eliminate inaccurate oxygen saturation data. The relationship between fraction of inspired oxygen (FiO2) andarterial oxygen saturation(SpO2) was assessed using a previously described methodology. Most infants had V/Q mismatch, while one had prevalent shunt.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
