T-wave alternans (TWA) is an every-other-beat fluctuation of the T-wave amplitude, often at microvolt (invisible) levels. It is recognized as an important risk index of severe ventricular arrhythmias, leading sometimes to sudden cardiac arrest. Many algorithms for automatic detection and quantification of TWA have been proposed; when applied to the same electrocardiogram (ECG), they may provide a different TWA quantification, making interpretation of differences difficult. Aim of this work is to propose TWA Simulator as a useful tool to validate and compare TWA identification methods. TWA Simulator is a user-friendly MATLAB graphical user interface (GUI) able to generate, model, visualize and store simulated ECG (SECG) affected by TWA of known morphology and amplitude. SECG is constructed by a Nfold repetition of a template, constituted by a real and clean ECG beat. Both number of beats and RR inter-beat variability can be set by the user. Both direct and inverted TWA can be simulated. Direct TWA is simulated by adding a waveform (among four possibility) to every other T wave; inverted TWA is simulated by changing T-wave polarity in every-other SECG beat. Availability of TWA Simulator would allow efficient validation and comparison of automatic TWA identification methods by helping interpretation of results
TWA Simulator: a Graphical User Interface for T-wave Alternans / Morettini, Micaela; Marchesini, Lorenzo; Pettinari, LUCA ALBERTO; Tigrini, Andrea; Marcantoni, Ilaria; Sbrollini, Agnese; Burattini, Laura. - In: COMPUTING IN CARDIOLOGY. - ISSN 2325-887X. - ELETTRONICO. - 45:(2018), pp. 1-4. (Intervento presentato al convegno 45th Computing in Cardiology Conference, CinC 2018 tenutosi a Maastricht, The Netherlands nel 23-26/09/2018) [10.22489/CinC.2018.044].
TWA Simulator: a Graphical User Interface for T-wave Alternans
Morettini, Micaela;PETTINARI, LUCA ALBERTO;TIGRINI, ANDREA;Marcantoni, Ilaria;Sbrollini, Agnese;Burattini, Laura
2018-01-01
Abstract
T-wave alternans (TWA) is an every-other-beat fluctuation of the T-wave amplitude, often at microvolt (invisible) levels. It is recognized as an important risk index of severe ventricular arrhythmias, leading sometimes to sudden cardiac arrest. Many algorithms for automatic detection and quantification of TWA have been proposed; when applied to the same electrocardiogram (ECG), they may provide a different TWA quantification, making interpretation of differences difficult. Aim of this work is to propose TWA Simulator as a useful tool to validate and compare TWA identification methods. TWA Simulator is a user-friendly MATLAB graphical user interface (GUI) able to generate, model, visualize and store simulated ECG (SECG) affected by TWA of known morphology and amplitude. SECG is constructed by a Nfold repetition of a template, constituted by a real and clean ECG beat. Both number of beats and RR inter-beat variability can be set by the user. Both direct and inverted TWA can be simulated. Direct TWA is simulated by adding a waveform (among four possibility) to every other T wave; inverted TWA is simulated by changing T-wave polarity in every-other SECG beat. Availability of TWA Simulator would allow efficient validation and comparison of automatic TWA identification methods by helping interpretation of resultsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.