In the present study we evaluated insulin action and secretion in a group of 7 young Zucker fatty rats (ZFR), and in a group of 8 spontaneously hypertensive rats (SHR), compared with two control groups of 7 young Zucker lean rats (ZLR) and 8 Wistar Kyoto rats (WKY), respectively. Our goal is to broaden the characterization of glucose tolerance, including insulin secretion, in two animal models used for the characterization of human metabolic syndrome: the ZFR and the SHR. Reliable estimates of insulin sensitivity index, SI, was provided by minimal model analysis of IVGTT data. To characterize insulin secretion we calculated an index based on IVGTT data: AIRG, i.e. the acute insulin response after glucose bolus, related to the first phase insulin secretion. The ZFR showed a significantly (p<0.005) lower mean estimate of SI, and a significantly (p<0.001) higher mean value of AIRG, compared to control groups (ZLR and WKY) and hypertensive rats (SHR). Thus, only the ZFR shows a reduced insulin action, compensated only partially by insulin hypersecretion. This suggests obesity, with respect to hypertension, as a primary factor in the deterioration of glucose tolerance. © Springer International Publishing Switzerland 2016.
The relative role of insulin action and secretion in experimental animal models of metabolic syndrome / Morettini, Micaela; DI NARDO, Francesco; Cogo, C. E.; Faelli, E.; Fioretti, Sandro; Burattini, Laura; Ruggeri, P.. - In: IFMBE PROCEEDINGS (CD). - ISSN 1727-1983. - 57:(2016), pp. 549-552. (Intervento presentato al convegno 14th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2016 tenutosi a cyp nel 2016) [10.1007/978-3-319-32703-7_107].
The relative role of insulin action and secretion in experimental animal models of metabolic syndrome
MORETTINI, MICAELA;DI NARDO, Francesco
;FIORETTI, Sandro;BURATTINI, LAURA;
2016-01-01
Abstract
In the present study we evaluated insulin action and secretion in a group of 7 young Zucker fatty rats (ZFR), and in a group of 8 spontaneously hypertensive rats (SHR), compared with two control groups of 7 young Zucker lean rats (ZLR) and 8 Wistar Kyoto rats (WKY), respectively. Our goal is to broaden the characterization of glucose tolerance, including insulin secretion, in two animal models used for the characterization of human metabolic syndrome: the ZFR and the SHR. Reliable estimates of insulin sensitivity index, SI, was provided by minimal model analysis of IVGTT data. To characterize insulin secretion we calculated an index based on IVGTT data: AIRG, i.e. the acute insulin response after glucose bolus, related to the first phase insulin secretion. The ZFR showed a significantly (p<0.005) lower mean estimate of SI, and a significantly (p<0.001) higher mean value of AIRG, compared to control groups (ZLR and WKY) and hypertensive rats (SHR). Thus, only the ZFR shows a reduced insulin action, compensated only partially by insulin hypersecretion. This suggests obesity, with respect to hypertension, as a primary factor in the deterioration of glucose tolerance. © Springer International Publishing Switzerland 2016.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
