Inhibitors of nicotinamide N-methyltransferase as tools for cancer treatment: effect on cell proliferation, apoptosis, oxidative stress and chemosensitivity.

Management of vaccinations in patients with non‐Hodgkin lymphoma

Vaccinations are fundamental tools in preventing infectious diseases, especially in immunocompromised patients like those affected by non-Hodgkin lymphomas (NHLs). The COVID-19 pandemic made clinicians increasingly aware of the importance of vaccinations in preventing potential life-threatening SARS-CoV-2-related complications in NHL patients. However, several studies have confirmed a significant reduction in vaccine-induced immune responses after anti-CD20 monoclonal antibody treatment, thus...

Noradrenaline modulates sensory information in mouse vomeronasal sensory neurons

: During the induction of the body's alert state, the sympathetic system modulates sensory modalities and fine-tunes peripheral organs for improved stimulus detection. We explored noradrenaline (NA)'s role in modulating signaling in vomeronasal sensory neurons (VSNs), responsible for detecting pheromones and other semiochemicals. In current-clamp recordings, NA increased the firing frequency in response to natural stimuli of responsive VSNs and induced spiking activity in previously unrespons...

Enhancing supply chain resilience through the supply network approach

Purpose This study aims to investigate the efficacy of the supply network approach in bolstering supply chain resilience amidst escalating global uncertainty. With enterprises worldwide facing increasing threats that disrupt supply chains, this research explores how firms enhance supply network resilience during crises. Design/methodology/approach Using a multi-case study design, this research thoroughly examines interactions within firms’ supply networks to uncover new insights on suppl...