Abstract Ghrelin, an acylated 28 amino acid gastric peptide, was isolated from the stomach as an endogenous ligand for growth hormone (GH) secretagogue receptor in 1999. Circulating ghrelin is mainly produced by specific cells in the stomach’s oxyntic glands. Ghrelin potently stimulates GH release and food intake and exhibits diverse effects, including ones on glucose metabolism and on secretion and motility of the gastrointestinal tract. Besides these effects on food intake and energy homeostasis, ghrelin is also involved in controlling reproductive functions, and a role for it as a novel regulator of the hypothalamic-pituitary gonadal axis is clearly emerging. We review recent ghrelin research with emphasis on its roles in the reproductive axis. Keywords: Ghrelin; Growth hormone; Energy homeostasis; Embryonic development; Reproduction
Ghrelin: a metabolic signal affecting the reproductive system / Lorenzi, T; Meli, R; Marzioni, Daniela; Morroni, Manrico; Baragli, A; Castellucci, Mario; Gualillo, O; Muccioli, G.. - In: CYTOKINE & GROWTH FACTOR REVIEWS. - ISSN 1359-6101. - 20:(2009), pp. 137-152. [10.1016/j.cytogfr.2009.02.003]
Ghrelin: a metabolic signal affecting the reproductive system
MARZIONI, Daniela;MORRONI, MANRICO;CASTELLUCCI, Mario;
2009-01-01
Abstract
Abstract Ghrelin, an acylated 28 amino acid gastric peptide, was isolated from the stomach as an endogenous ligand for growth hormone (GH) secretagogue receptor in 1999. Circulating ghrelin is mainly produced by specific cells in the stomach’s oxyntic glands. Ghrelin potently stimulates GH release and food intake and exhibits diverse effects, including ones on glucose metabolism and on secretion and motility of the gastrointestinal tract. Besides these effects on food intake and energy homeostasis, ghrelin is also involved in controlling reproductive functions, and a role for it as a novel regulator of the hypothalamic-pituitary gonadal axis is clearly emerging. We review recent ghrelin research with emphasis on its roles in the reproductive axis. Keywords: Ghrelin; Growth hormone; Energy homeostasis; Embryonic development; ReproductionI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
