The relationship between cerebrovascular impairment and Alzheimer's disease is a controversial debate. An important and topical aspect in clinical research is the attempt to define the role of atherosclerosis and its determinants in the presentation and evolution of dementia. In this article, we discuss the evidence of the interaction between degenerative and vascular mechanisms in the pathogenesis of dementia. Moreover, we present data about the influence of hypertension and dyslipidemia, usually considered among the most important risk factors for atherosclerosis, on the evolution of Alzheimer's disease. The effects of antihypertensive and lipid-lowering drugs on cognitive impairment will be also discussed.
Atherosclerosis in the evolution of Alzheimer's disease: can treatment reduce cognitive decline ? / Luzzi, Simona; Vella, L; Bartolini, Marco; Provinciali, Leandro; Silvestrini, Mauro. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 20(3):(2010), pp. 893-901. [10.3233/JAD-2010-091378]
Atherosclerosis in the evolution of Alzheimer's disease: can treatment reduce cognitive decline ?
LUZZI, SIMONA;BARTOLINI, MARCO;PROVINCIALI, LEANDRO;SILVESTRINI, Mauro
2010-01-01
Abstract
The relationship between cerebrovascular impairment and Alzheimer's disease is a controversial debate. An important and topical aspect in clinical research is the attempt to define the role of atherosclerosis and its determinants in the presentation and evolution of dementia. In this article, we discuss the evidence of the interaction between degenerative and vascular mechanisms in the pathogenesis of dementia. Moreover, we present data about the influence of hypertension and dyslipidemia, usually considered among the most important risk factors for atherosclerosis, on the evolution of Alzheimer's disease. The effects of antihypertensive and lipid-lowering drugs on cognitive impairment will be also discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
