Five programmed death-1/programmed death-ligand 1 (PD-L1) inhibitors are currently approved for the treatment of locally advanced or metastatic urothelial carcinoma of the bladder and the upper urinary tract. Following the FDA and EMA restrictions of first-line treatment with Atezolizumab and Pembrolizumab in platinum-ineligible patients, immunohistochemical PD-L1 testing is now re-quired. Several emerging issues on antibodies, test platforms and scoring algorithms have raised concerns about the comparability and interchangeability between these assays. In this review, we have fo-cused on the interchangeability of the used algorithms and assays for PD-L1 testing in urothelial car-cinoma, on the predictive reliability of PD-L1 testing in urothelial carcinoma and the potential of other new and upcoming biomarkers.
Pd-l1 testing for urothelial carcinoma: Interchangeability, reliability and future perspectives / Gevaert, T.; Cimadamore, A.; Montironi, R.; Eckstein, M.. - In: CURRENT DRUG TARGETS. - ISSN 1389-4501. - 22:2(2021), pp. 162-170. [10.2174/1389450121666200510015216]
Pd-l1 testing for urothelial carcinoma: Interchangeability, reliability and future perspectives
Cimadamore A.;Montironi R.;
2021-01-01
Abstract
Five programmed death-1/programmed death-ligand 1 (PD-L1) inhibitors are currently approved for the treatment of locally advanced or metastatic urothelial carcinoma of the bladder and the upper urinary tract. Following the FDA and EMA restrictions of first-line treatment with Atezolizumab and Pembrolizumab in platinum-ineligible patients, immunohistochemical PD-L1 testing is now re-quired. Several emerging issues on antibodies, test platforms and scoring algorithms have raised concerns about the comparability and interchangeability between these assays. In this review, we have fo-cused on the interchangeability of the used algorithms and assays for PD-L1 testing in urothelial car-cinoma, on the predictive reliability of PD-L1 testing in urothelial carcinoma and the potential of other new and upcoming biomarkers.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.