Glucose effectiveness (SG) represents the ability of glucose per se, under basal insulin concentrations, to stimulate its own uptake and to suppress its own production. SG and its two components BIE (Basal Insulin Effect) and GEZI (Glucose Effectiveness at Zero Insulin) are known to decline in subjects whose glycemic status worsens, but no study aimed to analyze whether changes may occur even before, when a normal glucose tolerance status is still preserved but insulin resistance has already arisen. To investigate this issue, SG, BIE and GEZI were estimated from the minimal model interpretation of frequently sampled intravenous glucose tolerance (FSIGT) test data in two groups of subjects with normal glucose tolerance (basal glycemia < 5.6 mmol/l): a group of control participants (CNT, n=50) and a group of subjects with pathologies or conditions causing insulin resistance (IR, n=50). No difference in mean values of SG was observed in the IR with respect to the CNT group (2.3 ± 0.9 vs. 2.5 ± 0.9 10-2 min-1; p = 0.17). BIE was found to be the minor component of SG in both CNT and IR group. The GEZI component provided a significantly higher proportional contribution to SG in the IR with respect to CNT (89% vs. 81% of SG, p <0.0001). In proportion, a significantly lower contribution was provided by BIE in IR group (11 ± 1 vs. 18 ± 1, p <0.0001). These results indicate that, at the real starting phase of the process of glucose tolerance impairment (reduced insulin action but normal tolerance), no variation in SG occurs with respect to normality. An increased proportional contribution of GEZI, when BIE declines, may allow the maintenance of normal glucose effectiveness.

No changes in glucose effectiveness in condition of reduced insulin action but preserved glucose tolerance as assessed by minimal model analysis / Morettini, Micaela; DI NARDO, Francesco; Fioretti, Sandro; Pacini, G.; Tura, A.; Burattini, Laura. - ELETTRONICO. - 65:(2017), pp. 1057-1060. (Intervento presentato al convegno Joint Conference of the European Medical and Biological Engineering Conference, EMBEC 2017 and Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2107 tenutosi a fin nel 2017) [10.1007/978-981-10-5122-7_264].

No changes in glucose effectiveness in condition of reduced insulin action but preserved glucose tolerance as assessed by minimal model analysis

MORETTINI, MICAELA;DI NARDO, Francesco;FIORETTI, Sandro;BURATTINI, LAURA
2017-01-01

Abstract

Glucose effectiveness (SG) represents the ability of glucose per se, under basal insulin concentrations, to stimulate its own uptake and to suppress its own production. SG and its two components BIE (Basal Insulin Effect) and GEZI (Glucose Effectiveness at Zero Insulin) are known to decline in subjects whose glycemic status worsens, but no study aimed to analyze whether changes may occur even before, when a normal glucose tolerance status is still preserved but insulin resistance has already arisen. To investigate this issue, SG, BIE and GEZI were estimated from the minimal model interpretation of frequently sampled intravenous glucose tolerance (FSIGT) test data in two groups of subjects with normal glucose tolerance (basal glycemia < 5.6 mmol/l): a group of control participants (CNT, n=50) and a group of subjects with pathologies or conditions causing insulin resistance (IR, n=50). No difference in mean values of SG was observed in the IR with respect to the CNT group (2.3 ± 0.9 vs. 2.5 ± 0.9 10-2 min-1; p = 0.17). BIE was found to be the minor component of SG in both CNT and IR group. The GEZI component provided a significantly higher proportional contribution to SG in the IR with respect to CNT (89% vs. 81% of SG, p <0.0001). In proportion, a significantly lower contribution was provided by BIE in IR group (11 ± 1 vs. 18 ± 1, p <0.0001). These results indicate that, at the real starting phase of the process of glucose tolerance impairment (reduced insulin action but normal tolerance), no variation in SG occurs with respect to normality. An increased proportional contribution of GEZI, when BIE declines, may allow the maintenance of normal glucose effectiveness.
2017
9789811051210
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/250219
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