Fullerene C60 is a nanoparticle being actively investigated for possible applications in biology and medicine since, owing to its lipophilicity, it should be able to be incorporated in or to permeate across a cellular membrane. Once exposing cells to such nanoparticles, the problem becomes how to assess the actual presence of fullerene in cells. Here we used a home-made broadband near-field scanning microwave microscope, in both time and frequency domains, and a commercial scanning capacitance microscope to investigate the ability of fullerene to permeate MCF-7 breast cancer cells. We found that, while the electromagnetic properties of the cell membrane are changed by fullerene exposure, surface roughness is a more reliable indicator of fullerene exposure.

Broadband near-field scanning microwave microscopy investigation of fullerene exposure of breast cancer cells / Farina, Marco; Piacenza, Francesco; De Angelis, Francesca; Mencarelli, Davide; Morini, Antonio; Venanzoni, Giuseppe; Pietrangelo, Tiziana; Malavolta, Marco; Basso, Andrea; Provinciali, Mauro; Hwang, James C.; Jin, Xin; DI DONATO, Andrea. - 2016-:(2016), pp. 1-4. (Intervento presentato al convegno 2016 IEEE MTT-S International Microwave Symposium, IMS 2016 tenutosi a usa, San Francisco nel 2016) [10.1109/MWSYM.2016.7540179].

Broadband near-field scanning microwave microscopy investigation of fullerene exposure of breast cancer cells

FARINA, Marco;MENCARELLI, Davide;MORINI, ANTONIO;DI DONATO, Andrea
2016-01-01

Abstract

Fullerene C60 is a nanoparticle being actively investigated for possible applications in biology and medicine since, owing to its lipophilicity, it should be able to be incorporated in or to permeate across a cellular membrane. Once exposing cells to such nanoparticles, the problem becomes how to assess the actual presence of fullerene in cells. Here we used a home-made broadband near-field scanning microwave microscope, in both time and frequency domains, and a commercial scanning capacitance microscope to investigate the ability of fullerene to permeate MCF-7 breast cancer cells. We found that, while the electromagnetic properties of the cell membrane are changed by fullerene exposure, surface roughness is a more reliable indicator of fullerene exposure.
2016
9781509006984
9781509006984
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/238752
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