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Chronically low NMNAT2 expression causes sub-lethal SARM1 activation and altered response to nicotinamide riboside in axons 1-gen-2024 Antoniou, Christina; Loreto, Andrea; Gilley, Jonathan; Merlini, Elisa; Orsomando, Giuseppe; Coleman, Michael P
SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides 1-gen-2024 Loreto, A.; Cramb, K. M. L.; Mcdermott, L. A.; Antoniou, C.; Cirilli, I.; Caiazza, M. C.; Merlini, E.; Arthur-Farraj, P.; Mock, E. D.; Zhao, H. T.; Bennett, D. L.; Orsomando, G.; Coleman, M. P.; Wade-Martins, R.
Adaptation of a Commercial NAD+ Quantification Kit to Assay the Base-Exchange Activity and Substrate Preferences of SARM1 1-gen-2024 Cirilli, I.; Amici, A.; Gilley, J.; Coleman, M. P.; Orsomando, G.
Adaptation of a commercial NAD quantification kit to assay the base exchange activity of SARM1 1-gen-2023 Cirilli, Ilenia; Amici, Adolfo; Gilley, Jonathan; Coleman, Michael P.; Orsomando, Giuseppe
The NAD + precursor NMN activates dSarm to trigger axon degeneration in Drosophila 1-gen-2022 Llobet Rosell, Arnau; Paglione, Maria; Gilley, Jonathan; Kocia, Magdalena; Gasparrini, Massimiliano; Cialabrini, Lucia; Raffaelli, Nadia; Angeletti, Carlo; Orsomando, Giuseppe; Coleman, Michael P.; Loreto, Andrea; Neukomm, Lukas J.
SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated by multiple physiologically relevant NAD metabolites 1-gen-2022 Angeletti, Carlo; Amici, Adolfo; Gilley, Jonathan; Loreto, Andrea; Trapanotto, Antonio G.; Antoniou, Christina; Merlini, Elisa; Coleman, Michael P.; Orsomando, Giuseppe
The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila 1-gen-2022 Llobet Rosell, Arnau; Paglione, Maria; Gilley, Jonathan; Kocia, Magdalena; Perillo, Giulia; Gasparrini, Massimiliano; Cialabrini, Lucia; Raffaelli, Nadia; Angeletti, Carlo; Orsomando, Giuseppe; Wu, Pei-Hsuan; Coleman, Michael P; Loreto, Andrea; Neukomm, Lukas Jakob
Programmed axon death executor SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated by physiological levels of NMN, NAD, NADP and other metabolites 1-gen-2021 Angeletti, Carlo; Amici, Adolfo; Gilley, Jonathan; Loreto, Andrea; Trapanotto, Antonio G.; Antoniou, Christina; Coleman, Michael P.; Orsomando, Giuseppe
Potent activation of SARM1 by NMN analogue VMN underlies vacor neurotoxicity 1-gen-2021 Loreto, Andrea; Angeletti, Carlo; Gilley, Jonathan; Arthur-Farraj, Peter; Merlini, Elisa; Amici, Adolfo; Desrochers, Laura M.; Wang, Qi; Orsomando, Giuseppe; Coleman, Michael P.
Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1 1-gen-2021 Loreto, A.; Angeletti, C.; Gu, W.; Osborne, A.; Nieuwenhuis, B.; Gilley, J.; Arthur-Farraj, P.; Merlini, E.; Amici, A.; Luo, Z.; Hartley-Tassell, L.; Ve, T.; Desrochers, L. M.; Wang, Q.; Kobe, B.; Orsomando, G.; Coleman, M. P.
BIALLELIC LOSS OF FUNCTION MUTATIONS IN NMNAT2 CAUSE PRENATAL CONTRACTURES, HYDROPS, BRAIN AND CRANIOFACIAL ABNORMALITIES 1-gen-2020 Hopkin, Rj; Lukacs, M; Gilley, J; Zhu, Y; Orsomando, G; Angeletti, C; Liu, J; Park, J; Coleman, M; Zhai, G; Witte, D; Stottmann, Rw
Functional characterization of COG1713 (YqeK) as a novel diadenosine tetraphosphate hydrolase family 1-gen-2020 Minazzato, Gabriele; Gasparrini, Massimiliano; Amici, Adolfo; Cianci, Michele; Mazzola, Francesca; Orsomando, Giuseppe; Sorci, Leonardo; Raffaelli, Nadia
Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration 1-gen-2020 Loreto, Andrea; Hill, Ciaran S; Hewitt, Victoria L; Orsomando, Giuseppe; Angeletti, Carlo; Gilley, Jonathan; Lucci, Cristiano; Sanchez-Martinez, Alvaro; Whitworth, Alexander J; Conforti, Laura; Dajas-Bailador, Federico; Coleman, Michael P
A nicotinamide phosphoribosyltransferase-GAPDH interaction sustains the stress-induced NMN/NAD+ salvage pathway in the nucleus 1-gen-2020 Grolla, Ambra A; Miggiano, Riccardo; Di Marino, Daniele; Bianchi, Michele; Gori, Alessandro; Orsomando, Giuseppe; Gaudino, Federica; Galli, Ubaldina; Del Grosso, Erika; Mazzola, Francesca; Angeletti, Carlo; Guarneri, Martina; Torretta, Simone; Calabrò, Marta; Boumya, Sara; Fan, Xiaorui; Colombo, Giorgia; Travelli, Cristina; Rocchio, Francesca; Aronica, Eleonora; Wohlschlegel, James A; Deaglio, Silvia; Rizzi, Menico; Genazzani, Armando A; Garavaglia, Silvia
Nicotinamide phosphoribosyltransferase (NAMPT) translocates to the nucleus following glyceraldehyde-3-phosphate dehydrogenase (GAPDH) interaction and confers DNA damage resistance to melanoma cells. 1-gen-2019 Grolla, Ambra A.; Miggiano, Riccardo; DI MARINO, Daniele; Bianchi, Michele; Orsomando, Giuseppe; Wohlschlegel, James A.; Genazzani, Armando A.; Garavaglia, Silvia
Homozygous NMNAT2 mutation in sisters with polyneuropathy and erythromelalgia 1-gen-2019 Huppke, Peter; Wegener, Eike; Gilley, Jonathan; Angeletti, Carlo; Kurth, Ingo; Drenth, Joost P. H.; Stadelmann, Christine; Barrantes-Freer, Alonso; Brück, Wolfgang; Thiele, Holger; Nürnberg, Peter; Gärtner, Jutta; Orsomando, Giuseppe; Coleman, Michael P.
Severe Biallelic Loss-of-function Mutations in Nicotinamide Mononucleotide Adenylyltransferase 2 (NMNAT2) in Two Fetuses with Fetal Akinesia Deformation Sequence 1-gen-2019 Lukacs, Marshall; Gilley, Jonathan; Zhu, Yi; Orsomando, Giuseppe; Angeletti, Carlo; Liu, Jiaqi; Yang, Xiuna; Park, Joun; Hopkin, Robert J.; Coleman, Michael P.; Grace Zhai, R.; Stottmann, Rolf W.
Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration 1-gen-2019 Loreto, Andrea; Hill, Ciaran S.; Hewitt, Victoria L.; Orsomando, Giuseppe; Angeletti, Carlo; Gilley, Jonathan; Lucci, Cristiano; Sanchez-Martinez, Alvaro; Whitworth, Alexander J.; Conforti, Laura; Dajas-Bailador, Federico; Coleman, Michael P.
Severe biallelic loss-of-function mutations in nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) in two fetuses with fetal akinesia deformation sequence 1-gen-2019 Lukacs, Marshall; Gilley, Jonathan; Zhu, Yi; Orsomando, Giuseppe; Angeletti, Carlo; Liu, Jiaqi; Yang, Xiuna; Park, Joun; Hopkin, Robert J; Coleman, Michael P; Zhai, R Grace; Stottmann, Rolf W
Homozygous NMNAT2 mutation in sisters with polyneuropathy and erythromelalgia 1-gen-2019 Huppke, Peter; Wegener, Eike; Gilley, Jonathan; Angeletti, Carlo; Kurth, Ingo; Drenth, Joost P. H.; Stadelmann, Christine; Barrantes-Freer, Alonso; Brück, Wolfgang; Thiele, Holger; Nürnberg, Peter; Gärtner, Jutta; Orsomando, Giuseppe; Coleman, Michael P.
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